ATP-Sensitive Potassium Channels in the Cerebral Circulation

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ATP-sensitive potassium channels in the cerebral circulation.

BACKGROUND In brain blood vessels, electrophysiological studies proving the existence of ATP-sensitive potassium channels (KATP) are scarce. However, numerous pharmacological studies establish the importance of KATP channels in these blood vessels. This review emphasizes the data supporting the importance of vascular KATP in the responses of brain blood vessels. SUMMARY OF REVIEW Electrophysi...

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Anti-nociceptive effect of cimetidine in mice: the role of ATP-sensitive potassium channels

Recent studies have shown that intracerebroventricular administration of cimetidine (CIM) induces anti-nociceptive and anti–inflammatory effects in rats. However, the underlying mechanism of CIM effect has not been determined yet. This study was planned to determine the anti-nociceptive effect of CIM (50 mg/kg, i.p.) in male mice (25-30 g, n = 80) using tail flick test. Also, the role of ATP-se...

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Anti-nociceptive effect of cimetidine in mice: the role of ATP-sensitive potassium channels

Recent studies have shown that intracerebroventricular administration of cimetidine (CIM) induces anti-nociceptive and anti–inflammatory effects in rats. However, the underlying mechanism of CIM effect has not been determined yet. This study was planned to determine the anti-nociceptive effect of CIM (50 mg/kg, i.p.) in male mice (25-30 g, n = 80) using tail flick test. Also, the role of ATP-se...

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Antioxidants inhibit ATP-sensitive potassium channels in cerebral arterioles.

BACKGROUND AND PURPOSE Hydrogen peroxide and peroxynitrite are capable of generating hydroxyl radical and are commonly suspected as sources of this radical in tissues. It would be useful to distinguish the source of hydroxyl radical in pathophysiological conditions and to clarify the mechanisms by which antioxidants modify vascular actions of oxidants. METHODS We investigated the effect of th...

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ژورنال

عنوان ژورنال: Stroke

سال: 2003

ISSN: 0039-2499,1524-4628

DOI: 10.1161/01.str.0000070425.98202.b5